Bibliografía científica sobre disrupciones endocrinas asociadas a pesticidas.


.
Theo Colborn, Diane Dumanoski & John Peterson Myers.

Pesticide

Compound
Hormone
system affected
Mechanism
References
Acetochlor
Thyroid
(decrease of thyroid hormone levels, increase in TSH)
Alachlor
Thyroid
(decrease of thyroid hormone levels, increase in TSH)
Aldrin
Estrogen
Binds
to estrogen receptors; competes with estradiol.
Allethrin,
d-trans
Estrogen
Amitrol
Thyroid
Thyroid
peroxidase inhibitors; inhibits thyroid hormone synthesis.
Atrazine
Neuroendocrine-pituitary
(depression of LH surge), testosterone metabolism.
Inhibits
ligand binding to androgen and estrogen receptors.
Carbaryl
Estrogen
and progesterone
Chlofentezine
Thyroid
Enhances
secretion of thyroid hormone.
Chlordane
Testosterone
and progesterone
Cypermethrin
Disruption
of reproductive function
DDT
Estrogen
DDT
and related compounds act in a number of ways to disrupt endocrine
function by binding with the estrogen receptor, including estrogen
mimickry and antagonism, altering the pattern of synthesis or metabolism
of hormones, and (4) modifying hormone receptor levels
DDT
Metabolite, p,p’-DDE
Androgen
Inhibits
androgen binding to the androgen receptor, androgen-induced transcriptional
activity, and androgen action in developing, pubertal and adult
male rats.
Dicofol
(Kelthane)
Estrogen
Dieldrin
Estrogen
Binds
to estrogen receptor;competes with estradiol.
Endosulfan
Estrogen
Ethylene
thiourea
Thyroid
Thyroid
peroxidase inhibitor.
Fenarimol
Estrogen
Estrogen
receptor agonist.
Fenbuconazole
Thyroid
Enhances
secretion of thyroid hormone.
Fenitrothion
Antiandrogen
Competitive
androgen receptor antagonist.
Fenvalerate
Estrogen
Fipronil
Thyroid
Enhances
secretion of thyroid hormone.
Heptachlor
Thyroid
Heptachlor-epoxide
Thyroid/Reproductive
Metabolite
of heptachlor
Reuber
1987

Iprodione
Inhibition
of testosterone synthesis
Karate
Thyroid
A
decrease of thyroid hormone in serum; direct effect on the thyroid
gland?
Kepone
(Chlordecone)
Estrogen
Displays
androgen and estrogen receptor-binding affinities.
Ketoconazole
Effects
on reproductive systems
Lindane
(Hexachlorocyclohexane)
Estrogen/Androgen
Inhibits
ligand binding to androgen and estrogen receptors.
Linuron
Androgen
Androgen
receptor antagonist.
Malathion
Thyroid
Significant
decrease of thyroid hormone in serum, with perhaps a direct effect
on the thyroid gland.
Mancozeb
Thyroid
Thyroid
peroxidase inhibitors.
Maneb
Thyroid
The
metabolite ethylenthiourea inhibits thyroid hormone synthesis.

Methomyl
Thyroid
Methoxychlor
Estrogen
Through
mechanisms other than receptor antagonism. Precise mechanism still
unclear.
Metribuzin
Thyroid
Mirex
Antiandrogenic
activity; inhibits production of LH. Potentially thyroid.
Nitrofen
Thyroid
Structural
similarities to the thyroid hormones; nitrofen or its metabolite
may have thyroid hormone activities.
Nonachlor,
trans-
Estrogen
Estrogen
receptor agonist?
Oxychlordane
Reproductive
Pendimethalin
Thyroid
Enhances
secretion of thyroid hormone.
Pentachloronitrobenzene
Thyroid
Enhances
secretion of thyroid hormone.
Permethrin
Estrogenic
Procymidone
Androgen
Androgen
receptor antagonist.
Prodiamine
Thyroid
Enhances
secretion of thyroid hormone.
Pyrimethanil
Thyroid
Enhances
secretion of thyroid hormone.
Sumithrin
Androgen
Tarstar
Thyroid
A
decrease of thyroid hormone in serum; direct effect on the thyroid
gland?
Thiazopyr
Thyroid
Enhances
secretion of thyroid hormone.
Thiram
Neuroendocrine-pituitary
(depression of LH surge), thyroid (decrease of T4, increase of TSH)
Toxaphene
Estrogen/
Thyroid
Triadimefon
Estrogen
Estrogen
receptor agonist.
Triadimenol
Estrogen
Estrogen
receptor agonist
Tributyltin
Reproductive
Trifluralin
Reproductive/
Metabolic
Vinclozolin
Androgen
Anti-androgenic.
(Competes with androgens for the androgen
receptor (AR), inhibits AR-DNA binding, and alters androgen-dependent
gene expression.)
Zineb
Thyroid
The
metabolite ethylenthiourea inhibits thyroid hormone synthesis.
Ziram
Thyroid
Inhibits
the iodide peroxidase. Structural similarities between ziram and
thiram; ziram can be metabolized to thiram in the environment.
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